When expecting father Alan discovers he has five siblings he's never met before, he decides to reconcile and meet his long lost family before his baby is born.
I loved Marlon Wayans in Requiem for a Dream, and it stands as a great example of how good of an actor he can be in a more serious, dramatic role. This is not the type of content that the majority of his filmography is composed of, however. Instead, most of his films (many of which he has written and produced) are low-brow parodies such as Scary Movie, Scary Movie 2, Dance Flick, and Fifty Shades of Black. Sextuplets is yet another example of that low-brow humour genre.
A quick look at the trailer and you know that this is quite heavily inspired by Eddie Murphy's The Nutty Professor and The Nutty Professor II: The Klumps, though the humour is more closely aligned with Adam Sandler's Jack and Jill. That being said, you could also say the same about Wayan's previous films White Chicks and Norbit.
This was never going to be a film that would be critically acclaimed (at least not in a good sense). Marlon Wayans plays multiple (seven) characters and they are all overly exaggerated. These stereotypical portrayals are over-the-top, but not in a way that manages to avoid clichés. It very quickly becomes very cringe as attempts at humour fall flat and drag on for far too long. To provide an example of one attempt at humour, a character wants to buy food from a vending machine. He puts his money in and [you can guess what happens]. The character is now frustrated but still hungry so he [does the most clichéd thing ever and] ends up in a predicament. It's the same overtired "jokes" we have seen time and time again.
One could put forward the idea that perhaps the film would be enjoyable if one was under the influence of certain substances, but the humour is so antiquated and juvenile, that one struggles to determine how that could be the case. Perhaps it is a cultural difference in comedy, but in this reviewers eyes, there is no originality, no charisma, and no reason to put yourself through watching it.
The plot is as strong as a wet paper towel and lacks any form of depth. There is just nothing going on that is interesting, nothing to keep you engaged, and I ended up turning the film off halfway through because I had yet to laugh once. Sure, I ended up finishing the film the next day, but it still hadn't managed to get even a chuckle out of me. Wayans needed to get a solid direction and side stories going on. Instead, he keeps introducing characters with little to no development, who forecast tired jokes too early and drag them out longer than necessary to stretch out the runtime. The jokes would appeal to children, but there are many aspects of the film that are not appropriate for a child, so it's hard to tell who the target audience is.
Coming from a large family (the youngest of 10 siblings) you would think Wayan would be able to create a cohesive story around these family members, but all he gets right is the frustration that many siblings can towards each other. Characters need an arc, and there was none of that here (the exclusion may be the character of "Ethan".
I can't in my right mind recommend wasting your time with this film. Go back and watch the Austin Powers trilogy; it's a much more competently executed film series.